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pentobarbital will lower the extent or impact of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Potent or average CYP3A4 inducers appreciably reduce guanfacine plasma concentrations and elimination 50 %-lifestyle.Following halting a CYP3A4 inducer, as the effects of your inducer decrease